This guidance note offers comprehensive background information and resources, along with guidelines and guidance for the UN system, in supporting Member States in their efforts to prevent and counter violent extremism and terrorism (P/CVE)—with a primary focus on preventing violent extremism (PVE). It proposes a model for gender mainstreaming across PVE efforts that is human rights–compliant. The objective of this document is not to provide a single template or one-size-fits-all approach for PVE—in part because a wide range of activities potentially falls under PVE—but more significantly because, to be successful, each context requires a human rights–compliant, gender-responsive, bespoke, and locally derived set of practices and policies.