Integrating gender equality in UNICEF’s programming is an ongoing process of building on what works, learning from mistakes, and then forging new frontiers. UNICEF has witnessed substantial contributions to gender equal outcomes through its gender-responsive actions, such as broadening its focus on adolescent girls and increasing their access to health and other services. The next leap for achieving sustainable outcomes for women and girls is to move beyond addressing immediate causes of poor health, malnutrition, or high risk to HIV to the underlying, root causes (such as patriarchal norms or control over women’s sexuality). A gender-transformative approach seeks to unveil the structural causes for gender inequalities so that programming efforts are able to create an enabling environment for women and girls to access services and resources as rightsholders and gender-equal partners without fail.