As Afghanistan marks one year since the Taliban took control, the humanitarian and human rights situation in the country is devastatingly grim, particularly for Afghan women and girls. Severe food insecurity, an economic crisis, human rights abuses targeting women and girls, and overt gender discrimination have brought Afghanistan to the brink of humanitarian collapse and eroded decades of progress towards development and gender equality. The United States’ withdrawal from Afghanistan and the international community’s shift in attention and resources to the conflict in Ukraine continue to exacerbate the breakdown of safety, rights, and assistance for Afghan women and girls. As this situation further deteriorates, the U.S. must show leadership and take action to mobilize the international community to center gender equality and human rights in all diplomatic, development, peacebuilding, and humanitarian engagement in Afghanistan.