This policy brief provides an overview of the entrenched gender inequalities and vulnerabilities which affected women and girls before the war and which have been exacerbated over the past 4 years. It then considers the specific impact of the conflict on women and girls’ health and protection. Particular attention is paid to GBV given its dramatic increase since the conflict started. The brief argues that the war is having a devastating impact on women and girls and that failure to include a stronger focus on gender considerations in the humanitarian response is causing irreparable damages to their lives. It then highlights the critical role of women in securing a response which addresses the needs and rights of Yemeni women and girls, and in ensuring that a gender transformative agenda is part of Yemen’s future. It concludes by setting out recommendations aimed at all humanitarian actors, including the need to increase funding towards GBV prevention and response as a matter of priority.