Since the emergence of the COVID-19 pandemic in December 2019, the effects on human lives have been devastating. The virus has spread across all 15-member states of the Economic Community of West African State (ECOWAS) recording more than 76,355 confirmed cases 1 and 1,323 fatalities as of June 30, 2020. The pandemic has impacted countries in the region differently, but its current and long-term impact indicates an adverse effect on the economic and social vulnerabilities of West Africa. Like most complex emergencies and crises, the gender dimensions of the pandemic pose a threat to pre-existing gender and other intersecting inequalities especially on 2 women and girls. This includes health, economic, security and social protection challenges.